Like all things, there are a lot of variables. How good and different are the two pitchers. How good is the hitting from the opposing team. So on and so forth. The most common thing I see is either pitcher #1 is super slow or fast and #2 is the complete opposite. Which then takes the opposing team one or two times around the order to get re-situated. I would imagine a more talented team is going to acclimate to the different pitcher more quickly.
My personal opinion is that there is little need to over-think it. Have a general rotation plan and watch/listen to your pitchers during warm ups. If something isn't working in the game, then pivot at that point to change momentum or timing.
My personal opinion is that there is little need to over-think it. Have a general rotation plan and watch/listen to your pitchers during warm ups. If something isn't working in the game, then pivot at that point to change momentum or timing.